Cathie Wood, the legendary investor, has adjusted the investment portfolio of her Ark Invest fund, providing a new direction for the US stock market this year. According to the latest trading news, Ark significantly increased its holdings in biotech, cryptocurrency-related companies, and Chinese technology stocks in late December 2025, while simultaneously selling Tesla (TSLA) and some cloud software and consumer technology stocks for arbitrage. This reflects Wood's predictions and strategic positioning for the 2026 stock market. The following is a compilation of news reports, purely for market observation and not investment advice.
Ark significantly increased its holdings in CRSP and healthcare-related biotech stocks.
Ark has strengthened its portfolio of medical biotech stocks, including those in gene editing and synthetic biology. Ark increased its holdings in CRISPR Therapeutics ( CRSP ) by approximately 156,000 shares, an investment of approximately $8.8 million. CRISPR Therapeutics focuses on developing breakthrough gene therapies using the CRISPR/Cas9 gene editing platform and is considered a key player in precision medicine.
In addition, Ark significantly increased its holdings in Pacific Biosciences of California (PACB) through its flagship ETF ARKK and ARKG, which focuses on gene therapy, purchasing a total of approximately 1.13 million shares, further expanding its stake in gene sequencing and life science tools. Other biotech stocks with slightly increased holdings include Beam Therapeutics (BEAM) and Twist Bioscience (TWST), demonstrating Ark's long-term confidence in gene editing and synthetic DNA technologies.
In the areas of autonomous driving and future transportation, Ark continues to bet on cutting-edge applications. The ARKQ ETF, focused on automation and robotics, purchased approximately 979,000 shares of WeRide (WRD), a developer of driverless taxis. Meanwhile, the ARKX ETF, focusing on space and advanced aviation, increased its holdings by approximately 447,000 shares of Archer Aviation (ACHR) and over 19,000 shares of AeroVironment (AVAV), positioning itself in the electric vertical takeoff and landing (eVTOL) and unmanned systems industries.
It's worth noting that Ark also increased its stake in Oklo (OKLO), a US-based nuclear microreactor company, by approximately 107,000 shares. This company focuses on providing next-generation stable power for AI data centers and defense computing, and is considered a potential beneficiary of the energy infrastructure development in the AI era.
Ark invests $50 million in Coinbase and Robinhood
In addition to biotech and future technologies, Ark has recently been actively buying back shares in cryptocurrencies and related financial platforms. In mid-December, Ark invested nearly $50 million in crypto trading and investment platforms such as Coinbase (COIN) and Robinhood (HOOD), betting on a potential new recovery in the cryptocurrency market before 2026.
Ark increased its stake in Alibaba (BABA), Baidu (BIDU), and WeRide (WRD).
In terms of regional allocation, Ark has also increased its exposure to Chinese technology stocks. Wood's funds purchased approximately $16.3 million worth of Alibaba (BABA) American Depositary Receipts (ADRs) while also increasing their holdings in Baidu (BIDU) and WeRide (WRD), indicating a reassessment of the prospects for China's artificial intelligence, cloud computing, and autonomous driving industries. (Source: Barron's)
Selling Tesla (TSLA) netted a profit of $30 million.
In contrast, Ark's selling activity was primarily concentrated in the electric vehicle and cloud software sectors. Through the ARKK, ARKW, and ARKQ ETFs, Ark collectively reduced its holdings of Tesla stock by 60,715 shares, realizing approximately $30 million. In addition, ARKW also adjusted its holdings in Cloudflare (NET), Palantir (PLTR), Roku (ROKU), and Shopify (SHOP), while other companies with minor reductions included Ibotta (IBTA) and Ionis Pharmaceuticals (IONS).
Wood is rebalancing her portfolio, gradually taking profits from previously overvalued and high-performing core AI technology stocks and increasing her holdings in areas she believes have disruptive innovation potential, including gene editing, biotechnology, crypto finance, autonomous driving, and new energy. This latest move demonstrates Wood's continued strong confidence in the long-term growth potential of biotech stocks and the role of cryptocurrency exchanges as the next wave of fintech infrastructure.
This article, "Investor Wood's Investment Allocation: Selling Tesla to Cash Out $30 Million, Heavily Investing in Biotech and Cryptocurrency Exchanges," first appeared on ABMedia .
